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1z7s
From Proteopedia
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|PDB= 1z7s |SIZE=350|CAPTION= <scene name='initialview01'>1z7s</scene>, resolution 3.20Å | |PDB= 1z7s |SIZE=350|CAPTION= <scene name='initialview01'>1z7s</scene>, resolution 3.20Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7s OCA], [http://www.ebi.ac.uk/pdbsum/1z7s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z7s RCSB]</span> | ||
}} | }} | ||
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[[Category: Wimmer, E.]] | [[Category: Wimmer, E.]] | ||
[[Category: Xiao, C.]] | [[Category: Xiao, C.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: G]] | ||
| - | [[Category: MYR]] | ||
| - | [[Category: a21]] | ||
| - | [[Category: capsid protein]] | ||
| - | [[Category: coxsackievirus]] | ||
[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | [[Category: picornavirus | + | [[Category: picornavirus,coxsackievirus,a21,capsid protein,viral protein]] |
| - | + | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:29 2008'' |
Revision as of 22:31, 30 March 2008
| |||||||
| , resolution 3.20Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The crystal structure of coxsackievirus A21
Overview
CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
About this Structure
1Z7S is a Protein complex structure of sequences from Human coxsackievirus a21. Full crystallographic information is available from OCA.
Reference
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874
Page seeded by OCA on Mon Mar 31 01:31:29 2008
