1zbd
From Proteopedia
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|PDB= 1zbd |SIZE=350|CAPTION= <scene name='initialview01'>1zbd</scene>, resolution 2.6Å | |PDB= 1zbd |SIZE=350|CAPTION= <scene name='initialview01'>1zbd</scene>, resolution 2.6Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zbd OCA], [http://www.ebi.ac.uk/pdbsum/1zbd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zbd RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Brunger, A T.]] | [[Category: Brunger, A T.]] | ||
[[Category: Ostermeier, C.]] | [[Category: Ostermeier, C.]] | ||
| - | [[Category: GTP]] | ||
| - | [[Category: MG]] | ||
| - | [[Category: ZN]] | ||
[[Category: effector]] | [[Category: effector]] | ||
[[Category: g protein]] | [[Category: g protein]] | ||
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[[Category: synaptic exocytosis]] | [[Category: synaptic exocytosis]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:33:34 2008'' |
Revision as of 22:33, 30 March 2008
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| , resolution 2.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A
Overview
The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state of Rab3A. The second interface consists of a deep pocket in Rab3A that interacts with a SGAWFF structural element of rabphilin-3A. Sequence and structure analysis, and biochemical data suggest that this pocket, or Rab complementarity-determining region (RabCDR), establishes a specific interaction between each Rab protein and its effectors. RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion.
About this Structure
1ZBD is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A., Ostermeier C, Brunger AT, Cell. 1999 Feb 5;96(3):363-74. PMID:10025402
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