2vp3

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|PDB= 2vp3 |SIZE=350|CAPTION= <scene name='initialview01'>2vp3</scene>, resolution 1.95&Aring;
|PDB= 2vp3 |SIZE=350|CAPTION= <scene name='initialview01'>2vp3</scene>, resolution 1.95&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5&#39;-DIPHOSPHATE'>M7G</scene>
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|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5&#39;-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] </span>
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp3 OCA], [http://www.ebi.ac.uk/pdbsum/2vp3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vp3 RCSB]</span>
}}
}}
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[[Category: Hodel, A E.]]
[[Category: Hodel, A E.]]
[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
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[[Category: M7G]]
 
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[[Category: SAH]]
 
[[Category: methyltransferase]]
[[Category: methyltransferase]]
[[Category: mrna processing]]
[[Category: mrna processing]]
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[[Category: vaccinia]]
[[Category: vaccinia]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:54:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:14:00 2008''

Revision as of 02:14, 31 March 2008


PDB ID 2vp3

Drag the structure with the mouse to rotate
, resolution 1.95Å
Ligands: ,
Activity: Polynucleotide adenylyltransferase, with EC number 2.7.7.19
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG


Overview

The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.

About this Structure

2VP3 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102

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