1uw1
From Proteopedia
(New page: 200px<br /> <applet load="1uw1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uw1, resolution 1.94Å" /> '''A NOVEL ADP- AND ZI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UW1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]]. | + | 1UW1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: nucleotide binding protein]] | [[Category: nucleotide binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:00:11 2007'' |
Revision as of 08:55, 30 October 2007
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A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION
Overview
A great challenge to biologists is to create proteins with novel folds and, tailored functions. As an alternative to de novo protein design, we, investigated the structure of a randomly generated protein targeted to, bind ATP. The crystal structure reveals a novel alpha/beta fold bound to, its ligand, representing both the first protein structure derived from in, vitro evolution and the first nucleotide-binding protein stabilized by a, zinc ion.
About this Structure
1UW1 is a [Single protein] structure of sequence from [[1]] with ZN and ADP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]
Page seeded by OCA on Tue Oct 30 11:00:11 2007
