2j37

From Proteopedia

(Difference between revisions)

Revision as of 05:34, 8 March 2018

MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS

Structural highlights

2j37 is a 8 chain structure with sequence from Canis sp., Haloarcula marismortui, Homo sapiens, Triticum sp. and Triticum sp.. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1dul, 1hq1, 1p85, 1p86, 2aw4, 2awb, 2j28
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SRP54_CANFA] Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Membrane and secretory proteins can be co-translationally inserted into or translocated across the membrane. This process is dependent on signal sequence recognition on the ribosome by the signal recognition particle (SRP), which results in targeting of the ribosome-nascent-chain complex to the protein-conducting channel at the membrane. Here we present an ensemble of structures at subnanometre resolution, revealing the signal sequence both at the ribosomal tunnel exit and in the bacterial and eukaryotic ribosome-SRP complexes. Molecular details of signal sequence interaction in both prokaryotic and eukaryotic complexes were obtained by fitting high-resolution molecular models. The signal sequence is presented at the ribosomal tunnel exit in an exposed position ready for accommodation in the hydrophobic groove of the rearranged SRP54 M domain. Upon ribosome binding, the SRP54 NG domain also undergoes a conformational rearrangement, priming it for the subsequent docking reaction with the NG domain of the SRP receptor. These findings provide the structural basis for improving our understanding of the early steps of co-translational protein sorting.

Following the signal sequence from ribosomal tunnel exit to signal recognition particle.,Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R Nature. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PMID:17086193^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R. Following the signal sequence from ribosomal tunnel exit to signal recognition particle. Nature. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PMID:17086193 doi:http://dx.doi.org/10.1038/nature05326

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j37"

@@ Line 1: / Line 1: @@
 ==MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS==
 <StructureSection load='2j37' size='340' side='right' caption='[[2j37]], [[Resolution|resolution]] 8.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2j37]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_sp. Canis sp.], [http://en.wikipedia.org/wiki/Canis_sp. Canis sp.], [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Triticum_sp. Triticum sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J37 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2j37]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_sp. Canis sp.], [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Triticum_sp. Triticum sp.] and [http://en.wikipedia.org/wiki/Triticum_sp. Triticum sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J37 FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dul|1dul]], [[1hq1|1hq1]], [[1p85|1p85]], [[1p86|1p86]], [[2aw4|2aw4]], [[2awb|2awb]], [[2j28|2j28]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j37 OCA], [http://pdbe.org/2j37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j37 RCSB], [http://www.ebi.ac.uk/pdbsum/2j37 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j37 OCA], [http://pdbe.org/2j37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j37 RCSB], [http://www.ebi.ac.uk/pdbsum/2j37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j37 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SRP54_CANFA SRP54_CANFA]] Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). [[http://www.uniprot.org/uniprot/SRP19_HUMAN SRP19_HUMAN]] Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
+[[http://www.uniprot.org/uniprot/SRP54_CANFA SRP54_CANFA]] Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j37_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j37_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j37 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">

2j37

From Proteopedia

Revision as of 05:34, 8 March 2018

MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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