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2m17

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Revision as of 22:59, 9 August 2018

ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1)

Structural highlights

2m17 is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Gene:	UBLCP1 (HUMAN)
Activity:	Phosphoprotein phosphatase, with EC number 3.1.3.16
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[UBCP1_HUMAN] Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.^[1] ^[2]

Publication Abstract from PubMed

The ubiquitin-like modifier (UBL) domain of ubiquitin-like domain proteins (UDPs) interacts specifically with subunits of the 26 S proteasome. A novel UDP, ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1), has been identified as an interacting partner of the 26 S proteasome. We determined the high-resolution solution structure of the UBL domain of human UBLCP1 by nuclear magnetic resonance spectroscopy. The UBL domain of hUBLCP1 has a unique beta-strand (beta3) and beta3-alpha2 loop, instead of the canonical beta4 observed in other UBL domains. The molecular topology and secondary structures are different from those of known UBL domains including that of fly UBLCP1. Data from backbone dynamics shows that the beta3-alpha2 loop is relatively rigid although it might have intrinsic dynamic profile. The positively charged residues of the beta3-alpha2 loop are involved in interacting with the C-terminal leucine-rich repeat-like domain of Rpn1.

Solution Structure and Rpn1 Interaction of the UBL Domain of Human RNA Polymerase II C-Terminal Domain Phosphatase.,Yun JH, Ko S, Lee CK, Cheong HK, Cheong C, Yoon JB, Lee W PLoS One. 2013 May 7;8(5):e62981. doi: 10.1371/journal.pone.0062981. Print 2013. PMID:23667555^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. PMID:15883030 doi:S0006-291X(05)00831-4
↑ Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon JE. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A. 2011 Sep 26. PMID:21949367 doi:10.1073/pnas.1113170108
↑ Yun JH, Ko S, Lee CK, Cheong HK, Cheong C, Yoon JB, Lee W. Solution Structure and Rpn1 Interaction of the UBL Domain of Human RNA Polymerase II C-Terminal Domain Phosphatase. PLoS One. 2013 May 7;8(5):e62981. doi: 10.1371/journal.pone.0062981. Print 2013. PMID:23667555 doi:10.1371/journal.pone.0062981

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m17"

Categories: Human | Phosphoprotein phosphatase | Lee, W | Yun, J | Hydrolase

@@ Line 1: / Line 1: @@
 ==ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1)==
 <StructureSection load='2m17' size='340' side='right' caption='[[2m17]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBLCP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m17 OCA], [http://pdbe.org/2m17 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m17 RCSB], [http://www.ebi.ac.uk/pdbsum/2m17 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m17 OCA], [http://pdbe.org/2m17 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m17 RCSB], [http://www.ebi.ac.uk/pdbsum/2m17 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m17 ProSAT]</span></td></tr>
 </table>
 == Function ==

2m17

From Proteopedia

Revision as of 22:59, 9 August 2018

ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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