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2mu8
From Proteopedia
(Difference between revisions)
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| - | == | + | ==Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum== |
<StructureSection load='2mu8' size='340' side='right' caption='[[2mu8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | <StructureSection load='2mu8' size='340' side='right' caption='[[2mu8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mu8 OCA], [http://pdbe.org/2mu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mu8 RCSB], [http://www.ebi.ac.uk/pdbsum/2mu8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mu8 OCA], [http://pdbe.org/2mu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mu8 RCSB], [http://www.ebi.ac.uk/pdbsum/2mu8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system. | ||
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| + | Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective.,Cifuentes G, Patarroyo ME, Urquiza M, Ramirez LE, Reyes C, Rodriguez R J Med Chem. 2003 May 22;46(11):2250-3. PMID:12747797<ref>PMID:12747797</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2mu8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:32, 9 December 2015
Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum
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