1ri5

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|GENE= ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])
|GENE= ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03291 Pox_MCEL]</span>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03291 Pox_MCEL]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB]</span>
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|RELATEDENTRY=[[1ri1|1RI1]], [[1ri2|1RI2]], [[1ri3|1RI3]], [[1ri4|1RI4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB]</span>
}}
}}
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[[Category: structural genomic]]
[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:02:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:28:30 2008''

Revision as of 20:28, 30 March 2008

Image:1ri5.gif


PDB ID 1ri5

Drag the structure with the mouse to rotate
, resolution 2.10Å
Gene: ECU10_0380 (Encephalitozoon cuniculi)
Domains: Pox_MCEL
Related: 1RI1, 1RI2, 1RI3, 1RI4


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure and mechanism of mRNA cap (guanine N-7) methyltransferase


Overview

A suite of crystal structures is reported for a cellular mRNA cap (guanine-N7) methyltransferase in complex with AdoMet, AdoHcy, and the cap guanylate. Superposition of ligand complexes suggests an in-line mechanism of methyl transfer, albeit without direct contacts between the enzyme and either the N7 atom of guanine (the attacking nucleophile), the methyl carbon of AdoMet, or the sulfur of AdoMet/AdoHcy (the leaving group). The structures indicate that catalysis of cap N7 methylation is accomplished by optimizing proximity and orientation of the substrates, assisted by a favorable electrostatic environment. The enzyme-ligand structures, together with new mutational data, fully account for the biochemical specificity of the cap guanine-N7 methylation reaction, an essential and defining step of eukaryotic mRNA synthesis.

About this Structure

1RI5 is a Single protein structure of sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of mRNA cap (guanine-N7) methyltransferase., Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD, Mol Cell. 2004 Jan 16;13(1):77-89. PMID:14731396

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