1yrh

From Proteopedia

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Revision as of 14:44, 12 October 2017

Crystal Structure Of Trp Repressor Binding Protein Wrba in complex with FMN

Structural highlights

1yrh is a 8 chain structure with sequence from "micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Related:	1ydg
Gene:	DRA0214 ("Micrococcus radiodurans" Raj et al. 1960)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[NQOR_DEIRA] It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The tryptophan repressor binding protein WrbA binds to the tryptophan repressor protein TrpR. Although the biological role of WrbA remains unclear, it has been proposed to function in enhancing the stability of TrpR-DNA complexes. Sequence database analysis has identified WrbA as a founding member of a flavodoxin-like family of proteins. Here we present crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas aeruginosa and their complexes with flavin mononucleotide. The protomer structure is similar to that of previously determined long-chain flavodoxins; however, each contains a conserved inserted region unique to the WrbA family. Interestingly, each WrbA protein forms a homotetramer with 222 symmetry, unique among flavodoxin-like proteins, in which each protomer binds one flavin mononucleotide cofactor molecule.

Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide.,Gorman J, Shapiro L Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gorman J, Shapiro L. Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide. Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580 doi:14/12/3004

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yrh"

@@ Line 1: / Line 1: @@
 ==Crystal Structure Of Trp Repressor Binding Protein Wrba in complex with FMN==
 <StructureSection load='1yrh' size='340' side='right' caption='[[1yrh]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
@@ Line 7: / Line 8: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ydg|1ydg]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRA0214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrh OCA], [http://pdbe.org/1yrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yrh RCSB], [http://www.ebi.ac.uk/pdbsum/1yrh PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1yrh TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrh OCA], [http://pdbe.org/1yrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yrh RCSB], [http://www.ebi.ac.uk/pdbsum/1yrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yrh ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1yrh TOPSAN]</span></td></tr>
 </table>
 == Function ==
@@ Line 19: / Line 20: @@
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yrh ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">

1yrh

From Proteopedia

Revision as of 14:44, 12 October 2017

Crystal Structure Of Trp Repressor Binding Protein Wrba in complex with FMN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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