2c5m

From Proteopedia

Revision as of 15:54, 5 November 2007

CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE

Overview

Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid, and phospholipid biosynthesis and its activity is increased in certain, human cancers, making it a promising drug target. The crystal structure of, the synthetase domain of human CTPS, which represents the first structure, of a CTPS from an eukaryote, has been determined. The structure is, homotetrameric and each active site is formed by three different subunits., Sulfate ions bound to the active sites indicate the positions of, phosphate-binding sites for the substrates ATP and UTP and the feedback, inhibitor CTP. Together with earlier structures of bacterial CTPS, the, human CTPS structure provides an extended understanding of the, structure-function relationship of CTPS-family members. The structure also, serves as a basis for structure-based design of anti-proliferative, inhibitors.

About this Structure

2C5M is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Active as CTP synthase, with EC number 6.3.4.2 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:16820675

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