1uou
From Proteopedia
(Difference between revisions)
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| - | == | + | |
| + | ==Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor== | ||
<StructureSection load='1uou' size='340' side='right' caption='[[1uou]], [[Resolution|resolution]] 2.11Å' scene=''> | <StructureSection load='1uou' size='340' side='right' caption='[[1uou]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMU:5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL)+METHYL)+URACIL'>CMU</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMU:5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL)+METHYL)+URACIL'>CMU</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uou OCA], [http://pdbe.org/1uou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uou RCSB], [http://www.ebi.ac.uk/pdbsum/1uou PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uou OCA], [http://pdbe.org/1uou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uou RCSB], [http://www.ebi.ac.uk/pdbsum/1uou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uou ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uo/1uou_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uo/1uou_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uou ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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[[Category: Ernill, R J]] | [[Category: Ernill, R J]] | ||
[[Category: Luke, R W.A]] | [[Category: Luke, R W.A]] | ||
| - | [[Category: | + | [[Category: McAlister, M S.B]] |
| - | [[Category: | + | [[Category: McCall, E J]] |
| - | [[Category: | + | [[Category: McMiken, H H.J]] |
[[Category: Minshull, C A]] | [[Category: Minshull, C A]] | ||
[[Category: Norman, R A]] | [[Category: Norman, R A]] | ||
Revision as of 08:07, 28 March 2018
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
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Categories: Human | Thymidine phosphorylase | Barry, S T | Bate, M | Breed, J | Colls, J G | Ernill, R J | Luke, R W.A | McAlister, M S.B | McCall, E J | McMiken, H H.J | Minshull, C A | Norman, R A | Paterson, D S | Pauptit, R A | Timms, D | Tucker, J A | Angiogenesis | Chemotaxis | Glycosyltransferase | Phosphorylase | Transferase
