1h3c
From Proteopedia
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==Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme== | ==Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme== | ||
<StructureSection load='1h3c' size='340' side='right' caption='[[1h3c]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='1h3c' size='340' side='right' caption='[[1h3c]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1h3c]] is a 3 chain structure | + | <table><tr><td colspan='2'>[[1h3c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H3C FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R79:N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE'>R79</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R79:N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE'>R79</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gsz|1gsz]], [[1h35|1h35]], [[1h36|1h36]], [[1h37|1h37]], [[1h39|1h39]], [[1h3a|1h3a]], [[1h3b|1h3b]], [[1sqc|1sqc]], [[2sqc|2sqc]], [[3sqc|3sqc]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gsz|1gsz]], [[1h35|1h35]], [[1h36|1h36]], [[1h37|1h37]], [[1h39|1h39]], [[1h3a|1h3a]], [[1h3b|1h3b]], [[1sqc|1sqc]], [[2sqc|2sqc]], [[3sqc|3sqc]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3c OCA], [http://pdbe.org/1h3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h3c RCSB], [http://www.ebi.ac.uk/pdbsum/1h3c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3c OCA], [http://pdbe.org/1h3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h3c RCSB], [http://www.ebi.ac.uk/pdbsum/1h3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3c ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h3c ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 27009]] | ||
[[Category: Squalene--hopene cyclase]] | [[Category: Squalene--hopene cyclase]] | ||
[[Category: Aebi, J D]] | [[Category: Aebi, J D]] | ||
Revision as of 04:34, 21 September 2017
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
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