2m1h
From Proteopedia
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==Solution structure of a PWWP domain from Trypanosoma brucei== | ==Solution structure of a PWWP domain from Trypanosoma brucei== | ||
<StructureSection load='2m1h' size='340' side='right' caption='[[2m1h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2m1h' size='340' side='right' caption='[[2m1h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1h OCA], [http://pdbe.org/2m1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m1h RCSB], [http://www.ebi.ac.uk/pdbsum/2m1h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1h OCA], [http://pdbe.org/2m1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m1h RCSB], [http://www.ebi.ac.uk/pdbsum/2m1h PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | TbTFIIS2-1, one of the two TFIIS homologues of Trypanosome brucei (T. brucei), cooperates with TbTFIIS1 in regulating transcription in T. brcuei. Structurally divergent from other TFIIS homologues from higher organisms, TbTFIIS2-1 contains an additional N-terminal PWWP domain besides other three conserved domains, which may imply potential role of TbTFIIS2-1 in transcription regulation. Here, we determined the solution structure of PWWP domain of TbTFIIS2-1 by NMR spectroscopy, which was the first solution structure of PWWP domain solved in trypanosomatid. In spite of poor sequence similarity between PWWP domains, this domain of TbTFIIS2-1 adopts a conserved 3D-structure, which contains a fi ve-stranded beta-barrel and a C-terminal alpha-helix. Furthermore, we found that TbTFIIS2-1 PWWP domain may be a protein-protein interaction module without the ability of DNA recognition and methyl-group interaction. This article is protected by copyright. All rights reserved. | ||
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| + | Solution structure of TbTFIIS2-1 PWWP domain from Trypanosoma brucei.,Wang R, Zhang J, Liao S, Tu X Proteins. 2016 Mar 23. doi: 10.1002/prot.25035. PMID:27005948<ref>PMID:27005948</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2m1h" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Elongation factor|Elongation factor]] | *[[Elongation factor|Elongation factor]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:08, 10 May 2016
Solution structure of a PWWP domain from Trypanosoma brucei
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Categories: Fan, K | Liao, S | Tu, X | Wang, R | Zhang, J | Transcription | Transcription factor
