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1uf2

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Revision as of 07:33, 28 March 2018

The Atomic Structure of Rice dwarf Virus (RDV)

Structural highlights

1uf2 is a 16 chain structure with sequence from Rice dwarf virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[P3_RDVA] Capsid protein which self-assembles to form the inner icosahedral capsid with a T=2 symmetry, and consisting of 60 P3 dimers.^[1] [P7_RDVO] Probable component of the transcriptional machinery present in the inner capsid. Displays dsRNA binding activity and may play an important role in the sorting of viral RNA and virion assembly. Together with the RNA-directed RNA polymerase P1 and capping enzyme P5, forms an transcriptional complex positioned near the channels situated at each of the five-fold vertices of the core.^[2] [P8_RDVO] Capsid protein which self-assembles to form the outer icosahedral capsid with a T=13 symmetry, about 70 nm in diameter and consisting of 780 molecules capsid proteins.

Publication Abstract from PubMed

Rice dwarf virus (RDV), the causal agent of rice dwarf disease, is a member of the genus Phytoreovirus in the family Reoviridae. RDV is a double-shelled virus with a molecular mass of approximately 70 million Dalton. This virus is widely prevalent and is one of the viruses that cause the most economic damage in many Asian countries. The atomic structure of RDV was determined at 3.5 A resolution by X-ray crystallography. The double-shelled structure consists of two different proteins, the core protein P3 and the outer shell protein P8. The atomic structure shows structural and electrostatic complementarities between both homologous (P3-P3 and P8-P8) and heterologous (P3-P8) interactions, as well as overall conformational changes found in P3-P3 dimer caused by the insertion of amino-terminal loop regions of one of the P3 protein into the other. These interactions suggest how the 900 protein components are built into a higher-ordered virus core structure.

The atomic structure of rice dwarf virus reveals the self-assembly mechanism of component proteins.,Nakagawa A, Miyazaki N, Taka J, Naitow H, Ogawa A, Fujimoto Z, Mizuno H, Higashi T, Watanabe Y, Omura T, Cheng RH, Tsukihara T Structure. 2003 Oct;11(10):1227-38. PMID:14527391^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Nakagawa A, Miyazaki N, Taka J, Naitow H, Ogawa A, Fujimoto Z, Mizuno H, Higashi T, Watanabe Y, Omura T, Cheng RH, Tsukihara T. The atomic structure of rice dwarf virus reveals the self-assembly mechanism of component proteins. Structure. 2003 Oct;11(10):1227-38. PMID:14527391
↑ Miyazaki N, Wu B, Hagiwara K, Wang CY, Xing L, Hammar L, Higashiura A, Tsukihara T, Nakagawa A, Omura T, Cheng RH. The functional organization of the internal components of Rice dwarf virus. J Biochem. 2010 Jun;147(6):843-50. doi: 10.1093/jb/mvq017. Epub 2010 Feb 26. PMID:20190042 doi:http://dx.doi.org/10.1093/jb/mvq017
↑ Nakagawa A, Miyazaki N, Taka J, Naitow H, Ogawa A, Fujimoto Z, Mizuno H, Higashi T, Watanabe Y, Omura T, Cheng RH, Tsukihara T. The atomic structure of rice dwarf virus reveals the self-assembly mechanism of component proteins. Structure. 2003 Oct;11(10):1227-38. PMID:14527391

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uf2"

@@ Line 1: / Line 1: @@
 ==The Atomic Structure of Rice dwarf Virus (RDV)==
 <StructureSection load='1uf2' size='340' side='right' caption='[[1uf2]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1uf2]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Rdv Rdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UF2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1uf2]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Rice_dwarf_virus Rice dwarf virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UF2 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uf2 OCA], [http://pdbe.org/1uf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1uf2 PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uf2 OCA], [http://pdbe.org/1uf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1uf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uf2 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 23: / Line 24: @@
 __TOC__
 </StructureSection>
-[[Category: Rdv]]
+[[Category: Rice dwarf virus]]
 [[Category: Cheng, R H]]
 [[Category: Fujimoto, Z]]

1uf2

From Proteopedia

Revision as of 07:33, 28 March 2018

The Atomic Structure of Rice dwarf Virus (RDV)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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