5aoe
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of pneumolysin D168A mutant.== | |
| - | + | <StructureSection load='5aoe' size='340' side='right' caption='[[5aoe]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aoe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aod|5aod]], [[5aof|5aof]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoe OCA], [http://pdbe.org/5aoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoe RCSB], [http://www.ebi.ac.uk/pdbsum/5aoe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoe ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Pee, K van]] | ||
[[Category: Yildiz, O]] | [[Category: Yildiz, O]] | ||
| - | [[Category: | + | [[Category: Cholesterol dependent cytolysin]] |
| + | [[Category: Pore forming toxin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 21:19, 5 October 2016
Crystal structure of pneumolysin D168A mutant.
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