5do9
From Proteopedia
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| - | ''' | + | ==Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q== |
| - | + | <StructureSection load='5do9' size='340' side='right' caption='[[5do9]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5do9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do9 OCA], [http://pdbe.org/5do9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do9 RCSB], [http://www.ebi.ac.uk/pdbsum/5do9 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: Tesmer, J | + | [[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity). |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Taylor, V G]] | ||
| + | [[Category: Tesmer, J J.G]] | ||
| + | [[Category: Gq-g11]] | ||
| + | [[Category: Gtp-binding protein alpha subunit]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Rgs protein]] | ||
Revision as of 17:21, 20 January 2016
Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q
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