5dof
From Proteopedia
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- | ''' | + | ==Crystal structure of Tetrahymena p19== |
+ | <StructureSection load='5dof' size='340' side='right' caption='[[5dof]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[5dof]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOF FirstGlance]. <br> | ||
+ | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
+ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5doi|5doi]], [[5dok|5dok]]</td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dof OCA], [http://pdbe.org/5dof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dof RCSB], [http://www.ebi.ac.uk/pdbsum/5dof PDBsum]</span></td></tr> | ||
+ | </table> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis. | ||
- | The | + | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.,Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M Nat Struct Mol Biol. 2015 Nov 9. doi: 10.1038/nsmb.3126. PMID:26551074<ref>PMID:26551074</ref> |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | + | </div> | |
- | + | <div class="pdbe-citations 5dof" style="background-color:#fffaf0;"></div> | |
- | + | == References == | |
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
[[Category: Lei, M]] | [[Category: Lei, M]] | ||
+ | [[Category: Tang, T]] | ||
[[Category: Wan, B]] | [[Category: Wan, B]] | ||
[[Category: Wu, J]] | [[Category: Wu, J]] | ||
- | [[Category: | + | [[Category: Dna binding protein]] |
+ | [[Category: Ob fold]] | ||
+ | [[Category: Telomerase]] | ||
+ | [[Category: Tetrahymena]] |
Revision as of 04:35, 1 December 2015
Crystal structure of Tetrahymena p19
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Categories: Lei, M | Tang, T | Wan, B | Wu, J | Dna binding protein | Ob fold | Telomerase | Tetrahymena