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5dok

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'''Unreleased structure'''
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==Crystal structure of Tetrahymena p45C==
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<StructureSection load='5dok' size='340' side='right' caption='[[5dok]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dok]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dof|5dof]], [[5doi|5doi]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dok OCA], [http://pdbe.org/5dok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dok RCSB], [http://www.ebi.ac.uk/pdbsum/5dok PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.
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The entry 5dok is ON HOLD until Paper Publication
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The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.,Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M Nat Struct Mol Biol. 2015 Nov 9. doi: 10.1038/nsmb.3126. PMID:26551074<ref>PMID:26551074</ref>
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Authors: Wan, B., Tang, T., Wu, J., Lei, M.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Crystal structure of Tetrahymena p45C
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<div class="pdbe-citations 5dok" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Lei, M]]
[[Category: Lei, M]]
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[[Category: Tang, T]]
[[Category: Wan, B]]
[[Category: Wan, B]]
[[Category: Wu, J]]
[[Category: Wu, J]]
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[[Category: Tang, T]]
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[[Category: Dna binding protein]]
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[[Category: Telomerase]]
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[[Category: Tetrahymena]]
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[[Category: Wh motif]]

Revision as of 04:38, 1 December 2015

Crystal structure of Tetrahymena p45C

5dok, resolution 2.30Å

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