Ivan Koutsopatriy estrogen receptor
From Proteopedia
(Difference between revisions)
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<scene name='71/714947/Antagonist_tamoxifen_bound_er/1'>Antagonist_tamoxifen_bound_er</scene> | <scene name='71/714947/Antagonist_tamoxifen_bound_er/1'>Antagonist_tamoxifen_bound_er</scene> | ||
| - | Tamoxifen is a drug created to bind ER and inhibit the transcription factor. Tamoxifen is larger than the hormone | + | Tamoxifen is a drug created to bind ER and inhibit the transcription factor activity of ER. Tamoxifen is larger than the normal hormone ER binds (estradiol); for this reason the activation loop is pushed into an inactive conformation. This blocks ER from giving the signal to grow. |
<scene name='71/714947/Er_bound_to_dna/1'>ER_bound_to_dna</scene> | <scene name='71/714947/Er_bound_to_dna/1'>ER_bound_to_dna</scene> | ||
Revision as of 20:13, 9 October 2015
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
