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4q1r
From Proteopedia
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==Galectin-1 in Complex with Ligand AN027== | ==Galectin-1 in Complex with Ligand AN027== | ||
| - | <StructureSection load='4q1r' size='340' side='right' caption='[[4q1r]], [[Resolution|resolution]] 1.47Å' scene=''> | + | <StructureSection load='4q1r' size='340' side='right'caption='[[4q1r]], [[Resolution|resolution]] 1.47Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4q1r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4q1r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1R FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XU:PROPYL+2-(ACETYLAMINO)-2-DEOXY-4-O-[3-O-({1-[2-(3-HYDROXYPHENYL)-2-OXOETHYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-BETA-D-GALACTOPYRANOSYL]-BETA-D-GLUCOPYRANOSIDE'>2XU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XU:PROPYL+2-(ACETYLAMINO)-2-DEOXY-4-O-[3-O-({1-[2-(3-HYDROXYPHENYL)-2-OXOETHYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-BETA-D-GALACTOPYRANOSYL]-BETA-D-GLUCOPYRANOSIDE'>2XU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q1p|4q1p]], [[4q26|4q26]], [[4q27|4q27]], [[4q2f|4q2f]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q1p|4q1p]], [[4q26|4q26]], [[4q27|4q27]], [[4q2f|4q2f]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1r OCA], [http://pdbe.org/4q1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1r RCSB], [http://www.ebi.ac.uk/pdbsum/4q1r PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1r OCA], [http://pdbe.org/4q1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1r RCSB], [http://www.ebi.ac.uk/pdbsum/4q1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | [[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | ||
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| + | ==See Also== | ||
| + | *[[Galectin|Galectin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Bertleff-Zieschang, N]] | [[Category: Bertleff-Zieschang, N]] | ||
[[Category: Grimm, C]] | [[Category: Grimm, C]] | ||
[[Category: Rational drug design]] | [[Category: Rational drug design]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 09:25, 24 April 2019
Galectin-1 in Complex with Ligand AN027
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