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Stepler sandbox STAT3

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==STAT3==
==STAT3==
<StructureSection load='1bg1' size='340' side='right' caption='STAT3 Interacting with DNA' scene=''>
<StructureSection load='1bg1' size='340' side='right' caption='STAT3 Interacting with DNA' scene=''>
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This is a default text for your page '''Stepler sandbox STAT3'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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STAT3 (Signal Transducer and Activator of Transcription 3) is one of seven of a family of homologous STAT proteins that differentially regulate gene expression. STAT 3 is important in both the development of embryos and
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing STAT3 <ref>PMID:9671298</ref> to the rescue.
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many functions in adult organisms. The STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. <ref>PMID:9671298</ref>
== Structure ==
== Structure ==
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<scene name='71/714950/Stat3_dimer_and_dna/1'>TextToBeDisplayed</scene>
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The STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. <ref>PMID:9671298</ref>
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The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein interacts with DNA</scene> by binding to the major groove of the DNA.
== Regulation ==
== Regulation ==
== DNA-Protein Interactions ==
== DNA-Protein Interactions ==
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The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein interacts with DNA</scene> by binding to the major groove of the DNA.
== Structural highlights ==
== Structural highlights ==

Revision as of 04:36, 13 October 2015

STAT3

STAT3 Interacting with DNA

Drag the structure with the mouse to rotate

References

  1. ↑ Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298 doi:10.1038/28101
  2. ↑ Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298 doi:10.1038/28101

Proteopedia Page Contributors and Editors (what is this?)

Cameron Stepler, Ann Taylor

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