4tpp
From Proteopedia
(Difference between revisions)
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==2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors== | ==2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors== | ||
<StructureSection load='4tpp' size='340' side='right' caption='[[4tpp]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='4tpp' size='340' side='right' caption='[[4tpp]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4tpp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TPP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4tpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TPP FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35D:1-[4-(3-{[1-(QUINOLIN-2-YL)AZETIDIN-3-YL]OXY}QUINOXALIN-2-YL)PIPERIDIN-1-YL]ETHANONE'>35D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35D:1-[4-(3-{[1-(QUINOLIN-2-YL)AZETIDIN-3-YL]OXY}QUINOXALIN-2-YL)PIPERIDIN-1-YL]ETHANONE'>35D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpm|4tpm]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpm|4tpm]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpp OCA], [http://pdbe.org/4tpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tpp RCSB], [http://www.ebi.ac.uk/pdbsum/4tpp PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpp OCA], [http://pdbe.org/4tpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tpp RCSB], [http://www.ebi.ac.uk/pdbsum/4tpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Chmait, S]] | [[Category: Chmait, S]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Phosphodiesterase 10a]] | [[Category: Phosphodiesterase 10a]] | ||
[[Category: Quinoline]] | [[Category: Quinoline]] | ||
Revision as of 09:16, 22 November 2017
2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors
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