5dik

From Proteopedia

(Difference between revisions)

Revision as of 08:05, 8 April 2020

Crystal structure of apo-lpg0406, a carboxymuconolactone decarboxylase family protein from Legionella pneumophila

Structural highlights

5dik is a 3 chain structure with sequence from Atcc 33152. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	5dip
Gene:	lptwr_00386, lpymg_00422 (ATCC 33152)
Activity:	Peroxiredoxin, with EC number 1.11.1.15
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[A0A0C9P2U2_LEGPN] Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.[SAAS:SAAS00088543]

Publication Abstract from PubMed

Lpg0406, a hypothetical protein from Legionella pneumophila, belongs to carboxymuconolactone decarboxylase (CMD) family. We determined the crystal structure of lpg0406 both in its apo and reduced form. The structures reveal that lpg0406 forms a hexamer and have disulfide exchange properties. The protein has an all-helical fold with a conserved thioredoxin-like active site CXXC motif and a proton relay system similar to that of alkylhydroperoxidase from Mycobacterium tuberculosis (MtAhpD), suggesting that lpg0406 might function as an enzyme with peroxidase activity and involved in antioxidant defense. A comparison of the size and the surface topology of the putative substrate-binding region between lpg0406 and MtAhpD indicates that the two enzymes accommodate the different substrate preferences. The structural findings will enhance understanding of the CMD family protein structure and its various functions.

Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila.,Chen X, Hu Y, Yang B, Gong X, Zhang N, Niu L, Wu Y, Ge H Protein Sci. 2015 Sep 24. doi: 10.1002/pro.2811. PMID:26402328^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chen X, Hu Y, Yang B, Gong X, Zhang N, Niu L, Wu Y, Ge H. Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila. Protein Sci. 2015 Sep 24. doi: 10.1002/pro.2811. PMID:26402328 doi:http://dx.doi.org/10.1002/pro.2811

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5dik"

@@ Line 1: / Line 1: @@
 ==Crystal structure of apo-lpg0406, a carboxymuconolactone decarboxylase family protein from Legionella pneumophila==
-<StructureSection load='5dik' size='340' side='right' caption='[[5dik]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='5dik' size='340' side='right'caption='[[5dik]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5dik]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5dik]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DIK FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dip|5dip]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lptwr_00386, lpymg_00422 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dik OCA], [http://pdbe.org/5dik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dik RCSB], [http://www.ebi.ac.uk/pdbsum/5dik PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dik OCA], [http://pdbe.org/5dik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dik RCSB], [http://www.ebi.ac.uk/pdbsum/5dik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dik ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 24: @@
 __TOC__
 </StructureSection>
+[[Category: Atcc 33152]]
+[[Category: Large Structures]]
 [[Category: Peroxiredoxin]]
 [[Category: Chen, X]]

5dik

From Proteopedia

Revision as of 08:05, 8 April 2020

Crystal structure of apo-lpg0406, a carboxymuconolactone decarboxylase family protein from Legionella pneumophila

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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