7,8-dihydro-8-oxoguanine triphosphatase
From Proteopedia
(Difference between revisions)
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'''7,8-dihydro-8-oxoguanine triphosphatase''' (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The ''E. coli'' DGTP is called '''MutT'''. The human DGTP is called '''MTH1'''. | '''7,8-dihydro-8-oxoguanine triphosphatase''' (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The ''E. coli'' DGTP is called '''MutT'''. The human DGTP is called '''MTH1'''. | ||
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| - | == Disease == | ||
== Relevance == | == Relevance == | ||
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The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA. | The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA. | ||
| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:47, 25 October 2015
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3D structures of 7,8-dihydro-8-oxoguanine triphosphatase
Updated on 25-October-2015
