4e6r
From Proteopedia
(Difference between revisions)
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==Crystal structure of a Cytoplasmic protein NCK2 (NCK2) from Homo sapiens at 2.20 A resolution== | ==Crystal structure of a Cytoplasmic protein NCK2 (NCK2) from Homo sapiens at 2.20 A resolution== | ||
<StructureSection load='4e6r' size='340' side='right' caption='[[4e6r]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4e6r' size='340' side='right' caption='[[4e6r]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMG:N,N-DIMETHYLGLYCINE'>DMG</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMG:N,N-DIMETHYLGLYCINE'>DMG</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC007195, GRB4, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC007195, GRB4, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6r OCA], [http://pdbe.org/4e6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e6r RCSB], [http://www.ebi.ac.uk/pdbsum/4e6r PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6r OCA], [http://pdbe.org/4e6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e6r RCSB], [http://www.ebi.ac.uk/pdbsum/4e6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e6r ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> | [[http://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> | ||
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| - | ==See Also== | ||
| - | *[[Growth factor receptor-bound protein|Growth factor receptor-bound protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: TCELL, Partnership for T-Cell Biology]] | [[Category: TCELL, Partnership for T-Cell Biology]] | ||
[[Category: Jcsg]] | [[Category: Jcsg]] | ||
| + | [[Category: Partnership for t-cell biology]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: PSI, Protein structure initiative]] | [[Category: PSI, Protein structure initiative]] | ||
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[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
| + | [[Category: Tcell]] | ||
Revision as of 08:00, 15 November 2017
Crystal structure of a Cytoplasmic protein NCK2 (NCK2) from Homo sapiens at 2.20 A resolution
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