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2jwq
From Proteopedia
(New page: 200px {{Structure |PDB= 2jwq |SIZE=350|CAPTION= <scene name='initialview01'>2jwq</scene> |SITE= <scene name='pdbsite=AC1:Mm0+Binding+Site+For+Residue+B+29'>AC1</s...) |
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| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum | + | |RELATEDENTRY= |
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB]</span> | ||
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[[Category: telomerase inhibitor]] | [[Category: telomerase inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:18 2008'' |
Revision as of 01:02, 31 March 2008
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study
Overview
The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.
About this Structure
2JWQ is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66. PMID:17385760
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