5dql
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of 2-vinyl glyoxylate modified isocitrate lyase from Mycobacterium tuberculosis== | |
| - | + | <StructureSection load='5dql' size='340' side='right' caption='[[5dql]], [[Resolution|resolution]] 1.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dql]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DQL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VGX:4-HYDROXY-2-OXOBUTANOIC+ACID'>VGX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dql OCA], [http://pdbe.org/5dql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dql RCSB], [http://www.ebi.ac.uk/pdbsum/5dql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dql ProSAT]</span></td></tr> |
| - | [[Category: Meek, T | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/ACEA1_MYCTE ACEA1_MYCTE]] Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It also catalyzes the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route).<ref>PMID:16689789</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Huang, H L]] | ||
| + | [[Category: Meek, T D]] | ||
| + | [[Category: Lyase-lyase inhibitor complex]] | ||
Revision as of 15:29, 14 September 2016
Crystal Structure of 2-vinyl glyoxylate modified isocitrate lyase from Mycobacterium tuberculosis
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