This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Acid phosphatase
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_1dkm| PDB=1dkm | SIZE=400| SCENE= |right|CAPTION=E. coli acid phosphatase [[1dkm]] }} | {{STRUCTURE_1dkm| PDB=1dkm | SIZE=400| SCENE= |right|CAPTION=E. coli acid phosphatase [[1dkm]] }} | ||
| + | |||
| + | == Function == | ||
'''Acid phosphatase''' (ACP, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H<sub>2</sub>O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.<br /> | '''Acid phosphatase''' (ACP, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H<sub>2</sub>O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.<br /> | ||
Revision as of 07:59, 25 October 2015
Contents |
Function
Acid phosphatase (ACP, EC number 3.1.3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.
Prostatic ACP (PSAP) is produced by the prostate.
Purple ACP (PAP) or tartrate-resistant ACP contains a dinuclear Fe center and their oxidized form in solution maintains a purple color.
Histidine ACP (HAP) catalyzes the transfer of phosphoryl group using an active-site histidine.
Disease
PSAP is found in increased amounts in patients who have prostate cancer.
Relevance
PSAP was used as a prostate cancer marker before the develpement of prostate specific antigen (PSA) as one.
3D Structures of acid phosphatase
Updated on 25-October-2015
