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Acid phosphatase

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{{STRUCTURE_1dkm| PDB=1dkm | SIZE=400| SCENE= |right|CAPTION=E. coli acid phosphatase [[1dkm]] }}
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== Function ==
== Function ==

Revision as of 11:41, 30 November 2015

Template:STRUCTURE 1dkm

Contents

Function

Acid phosphatase (ACP, EC number 3.1.3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.
Prostatic ACP (PSAP) is produced by the prostate.
Purple ACP (PAP) or tartrate-resistant ACP contains a dinuclear Fe center and their oxidized form in solution maintains a purple color.
Histidine ACP (HAP) catalyzes the transfer of phosphoryl group using an active-site histidine.

Disease

PSAP is found in increased amounts in patients who have prostate cancer.

Relevance

PSAP was used as a prostate cancer marker before the develpement of prostate specific antigen (PSA) as one.

3D Structures of acid phosphatase

Updated on 30-November-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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