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Actinin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | Actinins contain | + | Actinins contain four 3-helix bundles which are called spectrin repeat (SR). SR are found in proteins belonging to the cytoskeletal structure like spectrin and dystrophin. |
== 3D Structures of Actinin == | == 3D Structures of Actinin == | ||
Revision as of 09:44, 27 October 2015
Function
Actinin attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:
- ACTN1 encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.
- ACTN2 encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see Group:MUZIC:actinin2.
- ACTN3 encodes aA3 which anchors actin at the muscle Z-disk.
- ACTN4 encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis.
Structural highlights
Actinins contain four 3-helix bundles which are called spectrin repeat (SR). SR are found in proteins belonging to the cytoskeletal structure like spectrin and dystrophin.
3D Structures of Actinin
Updated on 27-October-2015
