Acylaminoacyl peptidase
From Proteopedia
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{{STRUCTURE_2hu7| PDB=2hu7 | SIZE=400| SCENE=|right|CAPTION=Acylaminoacyl peptidase dimer complex with acetyl and glycerol [[2hu7]]}} | {{STRUCTURE_2hu7| PDB=2hu7 | SIZE=400| SCENE=|right|CAPTION=Acylaminoacyl peptidase dimer complex with acetyl and glycerol [[2hu7]]}} | ||
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[[Acylaminoacyl peptidase]] or Acylamino-acid releasing enzyme ('''AARE''', EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1]) cleaves N-acetyl or N-formyl amino acid from the N-terminal of polypeptides. | [[Acylaminoacyl peptidase]] or Acylamino-acid releasing enzyme ('''AARE''', EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1]) cleaves N-acetyl or N-formyl amino acid from the N-terminal of polypeptides. | ||
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| + | == Structural highlights == | ||
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| + | AARE contains a C-terminal hydrolase and an N-terminal β-propeller domain. The enzyme exists in an open state in which the oxyanion active site is accessible to the substrate and in a closed state where the active site is blocked. | ||
__NOTOC__ | __NOTOC__ | ||
Revision as of 09:52, 25 October 2015
Function
Acylaminoacyl peptidase or Acylamino-acid releasing enzyme (AARE, EC number 3.4.19.1) cleaves N-acetyl or N-formyl amino acid from the N-terminal of polypeptides.
Structural highlights
AARE contains a C-terminal hydrolase and an N-terminal β-propeller domain. The enzyme exists in an open state in which the oxyanion active site is accessible to the substrate and in a closed state where the active site is blocked.
3D Structures of Acylaminoacyl peptidase
Updated on 25-October-2015
3o4g, 3o4h, 3o4i, 3o4j, 2hu5, 2hu7, 2hu8, 1ve6 – ApAARE – Aeropyrum pernix
2qr5, 2qzp – ApAARE (mutant)
1ve7 – ApAARE+p-nitrophenyl phosphate
3fnb – AARE – Streptococcus mutans
