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6-phosphogluconate dehydrogenase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''6-phosphogluconate dehydrogenase''' (6PGD) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH. | + | '''6-phosphogluconate dehydrogenase''' (6PGD) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.<ref>PMID:7922402</ref> |
== Disease == | == Disease == | ||
| - | 6PGD deficiency is an autosomal hereditary disease which manifests itself by abnormal breakdown of red blood cells. Treatment involves avoidance of drugs or foods which can cause hemolysis. | + | 6PGD deficiency is an autosomal hereditary disease which manifests itself by abnormal breakdown of red blood cells. Treatment involves avoidance of drugs or foods which can cause hemolysis.<ref>PMID:18159462</ref> |
</StructureSection> | </StructureSection> | ||
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**[[2iz0]] - Ll6PGD + inhibitor + ADP + NADP<BR /> | **[[2iz0]] - Ll6PGD + inhibitor + ADP + NADP<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:32, 6 December 2015
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3D structures of 6-phosphogluconate dehydrogenase
Updated on 06-December-2015
References
- ↑ Beam TR Jr. Quinolone therapy in intensive care unit settings. New Horiz. 1993 May;1(2):187-93. PMID:7922402
- ↑ Monga A, Makkar RP, Arora A, Mukhopadhyay S, Gupta AK. Case report: Acute hepatitis E infection with coexistent glucose-6-phosphate dehydrogenase deficiency. Can J Infect Dis. 2003 Jul;14(4):230-1. PMID:18159462
