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Acyl carrier protein

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'''Acyl carrier protein''' (ACP) is a component of the fatty acid biosynthesis cycle. ACP catalyzes the addition of a thioester to a phosphopantetheine moiety. The phosphopantetheine moiety is added post-translationally to ACP serine residue by ACP synthetase (ACPS). The phosphopantetheine contains a free SH group which binds acyl groups in the fatty acid biosynthesis as thioesters. The acyl groups from acetyl-CoA and malonyl-CoA are transferred to ACP. There are 2 types of ACP. '''ACP I''' is a multifunctional polypeptide found in yeast and mammals while '''ACP II''' is a monomeric protein found in bacteria and plants.
'''Acyl carrier protein''' (ACP) is a component of the fatty acid biosynthesis cycle. ACP catalyzes the addition of a thioester to a phosphopantetheine moiety. The phosphopantetheine moiety is added post-translationally to ACP serine residue by ACP synthetase (ACPS). The phosphopantetheine contains a free SH group which binds acyl groups in the fatty acid biosynthesis as thioesters. The acyl groups from acetyl-CoA and malonyl-CoA are transferred to ACP. There are 2 types of ACP. '''ACP I''' is a multifunctional polypeptide found in yeast and mammals while '''ACP II''' is a monomeric protein found in bacteria and plants.
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== Structural highlights ==
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The thioester - heptanethioate - is bound to ACP serine residue in an expandable hydrophobic cavity.
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Revision as of 09:00, 1 December 2015

Structure of E. coli acyl carrier protein complex with thioester, Zn+2 (grey) and Na+ (purple) ions (PDB code 2fad).

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3D structures of acyl carrier protein

Updated on 01-December-2015

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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