Hemolysin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_7ahl| PDB=7ahl | SIZE=400| SCENE= |right|CAPTION=α-hemolysin heptamer, [[7ahl]] }} | {{STRUCTURE_7ahl| PDB=7ahl | SIZE=400| SCENE= |right|CAPTION=α-hemolysin heptamer, [[7ahl]] }} | ||
| - | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. | + | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. |
See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]]. | See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]]. | ||
| Line 61: | Line 61: | ||
**[[2vk9]] - AT – ''Clostridium novyi''<br /> | **[[2vk9]] - AT – ''Clostridium novyi''<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:56, 21 March 2016
Hemolysin (HL) is exotoxin from bacteria which causes lysis of red blood cells[1]. Hemolysin from the bacterium Clostridium are called alpha-toxin (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C.
See details for α-hemolysin in Pore forming toxin, α-hemolysin. See details of hemolysin E in Molecular Playground/ClyA.
For toxins in Proteopdia see Toxins.
3D Structures of hemolysin
Updated on 21-March-2016
A full page in Proteopedia exploring 7ahl is found here.
References
- ↑ Mestre MB, Fader CM, Sola C, Colombo MI. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells. Autophagy. 2010 Jan;6(1):110-25. PMID:20110774
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Mark Hoelzer, Wayne Decatur, Alexander Berchansky
