Arrestin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='2wtr' size='340' side='right' caption='Bovine arrestin-2 complex with Ba+2 ions (PDB code [[2wtr]])' scene=''> | <StructureSection load='2wtr' size='340' side='right' caption='Bovine arrestin-2 complex with Ba+2 ions (PDB code [[2wtr]])' scene=''> | ||
| - | '''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions. | ||
== Function == | == Function == | ||
| - | + | '''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions. | |
| - | + | ||
| - | + | ||
== Structural highlights == | == Structural highlights == | ||
| + | |||
| + | ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:31, 4 November 2015
| |||||||||||
3D Structures of arrestin
Updated on 04-November-2015
