Basic Pancreatic Trypsin Inhibitor
From Proteopedia
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<StructureSection load='3tgi' size='450' side='right' scene= caption='Bovine BPTI (wheat) complex with trypsin (magenta), sulfate and Ca+2 ion (green) (PDB code [[3tgi]])'> | <StructureSection load='3tgi' size='450' side='right' scene= caption='Bovine BPTI (wheat) complex with trypsin (magenta), sulfate and Ca+2 ion (green) (PDB code [[3tgi]])'> | ||
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| + | == Function == | ||
[[Basic Pancreatic Trypsin Inhibitor]] (BPTI) is a small protein which inhibits trypsin and related proteases. For other trypsin inhibitors see [[Trypsin inhibitor]]. | [[Basic Pancreatic Trypsin Inhibitor]] (BPTI) is a small protein which inhibits trypsin and related proteases. For other trypsin inhibitors see [[Trypsin inhibitor]]. | ||
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| + | == Relevance == | ||
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| + | BPTI is used as drug called Aprotinin used to reduce bleeding during surgery. | ||
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| + | == Structural highlights == | ||
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| + | Residue K15 of BPTI extends into the active site of trypsin and inhibits its proteolytic function. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:39, 9 November 2015
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3D Structures of BPTI
Updated on 09-November-2015
