Beta-2 microglobulin
From Proteopedia
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| - | {{STRUCTURE_3mrb| PDB=3mrb | SIZE= | + | {{STRUCTURE_3mrb| PDB=3mrb | SIZE=350| SCENE= |right|CAPTION=Human β-2 microglobulin (green) complex with MHC I (grey) and HCMV PP65 nonapeptide (cyan), [[3mrb]] }} |
[[Image:MHC Class 1.png|thumb|200px|left|Diagram of MHC I Complex]] | [[Image:MHC Class 1.png|thumb|200px|left|Diagram of MHC I Complex]] | ||
Revision as of 08:52, 30 November 2015
Beta-2 microglobulin (B2M) is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. For more details, see: Human beta two microglobulin.
Disease
Elevated B2M levels are found in patients of live cirhossis.
Relevance
B2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma.
3D Structures of β-2 microglobulin
Updated on 30-November-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, David Canner
