Bile acid receptor
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Bile acid receptor or farnesoid X receptor''' (FXR) binds bile acids, then translocates to the nucleus, forms a dimer and binds to hormone response elements. This causes up- or down-regulation of certain genes involved in cholesterol metabolism, lipid homeostasis and absorption of fats and vitamins. FXR ligand-binding domain (LBD) binds chenodeoxycholic acid (CDC), lithocholic acid and deoxycholic acid. | + | '''Bile acid receptor or farnesoid X receptor''' (FXR) binds bile acids, then translocates to the nucleus, forms a dimer and binds to hormone response elements. This causes up- or down-regulation of certain genes involved in cholesterol metabolism, lipid homeostasis and absorption of fats and vitamins. FXR ligand-binding domain (LBD) binds chenodeoxycholic acid (CDC), lithocholic acid and deoxycholic acid. <ref>PMID:23982684</ref> |
== Disease == | == Disease == | ||
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[[3fxv]], [[3gd2]], [[3okh]], [[3oki]], [[3olf]], [[3omk]], [[3omm]], [[3oof]], [[3ook]], [[3p88]], [[3p89]] – hFXR LBD (mutant) + non-steroidal agonist + nuclear receptor coactivator 1 peptide<br /> | [[3fxv]], [[3gd2]], [[3okh]], [[3oki]], [[3olf]], [[3omk]], [[3omm]], [[3oof]], [[3ook]], [[3p88]], [[3p89]] – hFXR LBD (mutant) + non-steroidal agonist + nuclear receptor coactivator 1 peptide<br /> | ||
[[1ot7]] – hFXR LBD + CDC derivative + RPGR-interacting protein peptide<br /> | [[1ot7]] – hFXR LBD + CDC derivative + RPGR-interacting protein peptide<br /> | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:22, 18 November 2015
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