Anthrax protective antigen
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1acc' size='450' side='right' caption='Anthrax protective antigen (PA83) complex with Ca+2 ions (PDB code [[1acc]])' scene='48/485625/Cv/ | + | <StructureSection load='1acc' size='450' side='right' caption='Anthrax protective antigen (PA83) complex with Ca+2 ions (PDB code [[1acc]])' scene='48/485625/Cv/7'> |
== Function == | == Function == | ||
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PA contains 4 domains:<br /> | PA contains 4 domains:<br /> | ||
| - | * <scene name='48/485625/Cv/3'>Domain 1 | + | * <scene name='48/485625/Cv/3'>Domain 1</scene> is the N terminal (in yellow). It contains the furin protease cleavage site enabling the release of PA20.<br /> |
| - | * Domain 2 (in cyan) is the heptamerization domain of PA63.<br /> | + | * <scene name='48/485625/Cv/4'>Domain 2</scene> (in cyan) is the heptamerization domain of PA63.<br /> |
| - | * Domain 3 (in salmon) forms the heptameric pore with domain 2 and enabling LF and EF to penetrate the cell.<br /> | + | * <scene name='48/485625/Cv/5'>Domain 3</scene> (in salmon) forms the heptameric pore with domain 2 and enabling LF and EF to penetrate the cell.<br /> |
| - | * Domain 4 (in magenta) is important for receptor recognition and pore formation. <br /> | + | * <scene name='48/485625/Cv/6'>Domain 4</scene> (in magenta) is important for receptor recognition and pore formation. <br /> |
</StructureSection> | </StructureSection> | ||
Revision as of 13:49, 11 November 2015
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3D structures of anthrax protective antigen
Updated on 11-November-2015
