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Botulinum neurotoxin
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'''Botulinum neurotoxin''' (CBN) is produced by the bacterium ''Clostridium botulinum''. CBP contains a light (residues 1-440) and a heavy (residues 441-875) chains (LC and HC). CBP LC proteolyzes SNARE substrates which are essential for synaptic vescicle fusion and neurotransmitter release thus causing paralysis. CBP HC acts as a channel and as transmembrane chaperone enabling the passage of the LC into the cytosol. The bacteria produces 8 neurotoxins which differ in their antigens.<br /> | '''Botulinum neurotoxin''' (CBN) is produced by the bacterium ''Clostridium botulinum''. CBP contains a light (residues 1-440) and a heavy (residues 441-875) chains (LC and HC). CBP LC proteolyzes SNARE substrates which are essential for synaptic vescicle fusion and neurotransmitter release thus causing paralysis. CBP HC acts as a channel and as transmembrane chaperone enabling the passage of the LC into the cytosol. The bacteria produces 8 neurotoxins which differ in their antigens.<br /> | ||
*'''Botulinum neurotoxin type A''' is the potent disease agent in botulism.<br /> | *'''Botulinum neurotoxin type A''' is the potent disease agent in botulism.<br /> | ||
| - | *'''Botulinum neurotoxin type B''' is used for treatment of severe spasms in the neck muscles [[Clostridium Botulinum Neurotoxin Type B]]. <br /> | + | *'''Botulinum neurotoxin type B''' is used for treatment of severe spasms in the neck muscles. See [[Clostridium Botulinum Neurotoxin Type B]]. <br /> |
*'''Botulinum neurotoxin type C''' induces apoptotic cell death in cerebellar neurons acting in birds, mammals and fish.<br /> | *'''Botulinum neurotoxin type C''' induces apoptotic cell death in cerebellar neurons acting in birds, mammals and fish.<br /> | ||
*'''Botulinum neurotoxin type D''' inhibits the release of TNF from monocytes.<br /> | *'''Botulinum neurotoxin type D''' inhibits the release of TNF from monocytes.<br /> | ||
Revision as of 10:27, 12 November 2015
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3D structures of botulinum neurotoxin
Updated on 12-November-2015
