Gunnar Reiske/Sandbox 102
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='1yr2' size='500' side='right' background='none' caption='"Prolyl endopeptidases (PEPs) are a unique class of serine proteases with considerable therapeutic potential for the treatment of celiac sprue." (2005) Proc.Natl.Acad.Sci.USA 102: 3599-3604 (pubmed?) (PDB code [[1yr2]])'> | <StructureSection load='1yr2' size='500' side='right' background='none' caption='"Prolyl endopeptidases (PEPs) are a unique class of serine proteases with considerable therapeutic potential for the treatment of celiac sprue." (2005) Proc.Natl.Acad.Sci.USA 102: 3599-3604 (pubmed?) (PDB code [[1yr2]])'> | ||
| + | |||
| + | == Background == | ||
| + | |||
The protein, gluten is found in wheat and grains such as rye and barley. Gluten is also involved with inducing an inflammatory response in individuals with celiac disease. Individuals who have the disease cannot digest gluten due to the protein’s structure, which will damage the small intestine. In detail, if an individual with celiac disease ingests foods containing gluten, the immune system responds by damaging the villi, which are fingerlike projections lining the small intestine. This type of immune response denies the body’s ability to absorb nutrients that pass through the small intestine and into the bloodstream. As a result of the damaged villi, people with celiac disease can become malnourished. Although celiac disease is genetic, the question of how the protein triggers an immune response in the gastrointestinal tract of affected individuals was further explored. | The protein, gluten is found in wheat and grains such as rye and barley. Gluten is also involved with inducing an inflammatory response in individuals with celiac disease. Individuals who have the disease cannot digest gluten due to the protein’s structure, which will damage the small intestine. In detail, if an individual with celiac disease ingests foods containing gluten, the immune system responds by damaging the villi, which are fingerlike projections lining the small intestine. This type of immune response denies the body’s ability to absorb nutrients that pass through the small intestine and into the bloodstream. As a result of the damaged villi, people with celiac disease can become malnourished. Although celiac disease is genetic, the question of how the protein triggers an immune response in the gastrointestinal tract of affected individuals was further explored. | ||
| Line 7: | Line 10: | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | |||
| - | == Function == | ||
== Disease == | == Disease == | ||
| - | == | + | == Gluten Complex == |
| - | == | + | === Function === |
| - | + | === Relevance === | |
| - | == | + | == Relevant Proteins == |
| - | == HLA-DQ2 == | + | === HLA-DQ2 === |
| - | == HLA-DQ8 == | + | === HLA-DQ8 === |
| - | == 1yr2(placeholder) == | + | === 1yr2(placeholder) === |
| - | == 2bkl(placeholder) == | + | === 2bkl(placeholder) === |
| + | |||
| + | == Structural highlights == | ||
| + | |||
| + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 21:57, 15 November 2015
How Gluten Protein Structure Stimulates an Immune Response
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Proteopedia Page Contributors and Editors (what is this?)
Ben Horansky, Devin Joseph, Premal Patel, Gunnar Reiske, Katlin Cannon
