This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Calcineurin
From Proteopedia
| Line 24: | Line 24: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1tco]] – CN + FK-506-binding protein + Ca + Fe + Zn – bovine<br /> | + | [[1tco]] – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine<br /> |
| - | [[1aui]] - hCN + Ca + Fe + Zn – human<br /> | + | [[1aui]] - hCN subunit A, B + Ca + Fe + Zn – human<br /> |
| - | [[4il1]] – CN + Ca – rat<br /> | + | [[4il1]] – CN subunit A, B/calmodulin + Ca – rat<br /> |
[[1m63]], [[1mf8]] - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn<br /> | [[1m63]], [[1mf8]] - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn<br /> | ||
| - | [[2p6b]] - hCN + PVIVIT peptide + Ca + Fe + Zn<br /> | + | [[2p6b]] - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn<br /> |
| - | [[3ll8]] - hCN + AKAP79 peptide + Ca + Fe + Zn<br /> | + | [[3ll8]] - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn<br /> |
| - | [[2jog]] - hCN | + | [[2jog]] - hCN subunit A + NFAT peptide<br /> |
| - | [[ | + | [[2w73]], [[2jzi]] - hCN subunit A calmodulin-binding domain + calmodulin + Ca<br /> |
| - | [[ | + | |
[[4f0z]] – hCN subunit B + African swine protein virus + Ca<br /> | [[4f0z]] – hCN subunit B + African swine protein virus + Ca<br /> | ||
Revision as of 10:50, 16 November 2015
Contents |
Function
Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. For more details see Group:MUZIC:Calcineurin.
Relevance
CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine.
Structural highlights
It contains a calmodulin-binding catalytic subunit A and a Ca+2-binding regulatory subunit B. There are 2 metal ions in CN active site.
3D structures of calcineurin
Updated on 16-November-2015
1tco – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine
1aui - hCN subunit A, B + Ca + Fe + Zn – human
4il1 – CN subunit A, B/calmodulin + Ca – rat
1m63, 1mf8 - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn
2p6b - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn
3ll8 - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn
2jog - hCN subunit A + NFAT peptide
2w73, 2jzi - hCN subunit A calmodulin-binding domain + calmodulin + Ca
4f0z – hCN subunit B + African swine protein virus + Ca
