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Catechol O-methyltransferase

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<StructureSection load='3a7e' size='450' side='right' caption='Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry [[3a7e]])' scene='55/551215/Cv/1'>
<StructureSection load='3a7e' size='450' side='right' caption='Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry [[3a7e]])' scene='55/551215/Cv/1'>
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== Function ==
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'''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction.
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== Relevance ==
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The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.<ref>PMID:19111934</ref>
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==Structural highlights ==
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'''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.<ref>PMID:19111934</ref>
 
*<scene name='55/551215/Cv/2'>Active site of human catechol O-methyltransferase complex with SAM and dinitrocatechol</scene> (PDB entry [[3a7e]]).
*<scene name='55/551215/Cv/2'>Active site of human catechol O-methyltransferase complex with SAM and dinitrocatechol</scene> (PDB entry [[3a7e]]).
</StructureSection>
</StructureSection>

Revision as of 10:49, 23 November 2015

Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry 3a7e)

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3D Structures of catechol O-methyltransferase

Updated on 23-November-2015

References

  1. ↑ Tsuji E, Okazaki K, Isaji M, Takeda K. Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase. J Struct Biol. 2008 Dec 10. PMID:19111934 doi:S1047-8477(08)00293-1

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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