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Catenin
From Proteopedia
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<br /> | [[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<br /> | ||
* '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br /> | * '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br /> | ||
Revision as of 07:50, 29 November 2015
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Contents |
Function
Catenins (CTN) are proteins which make complexes with cadherin.
- α-CTN links cadherin (CDH) and α-actinin, it is encoded by 3 genes: α-E-CTN (epithelial), α-T-CTN (membrane bound), and α-N-CTN (neuronal).
- β-CTN is a subunit of the cadherin complex. It contains Armadillo repeats which are a pair of helices forming hairpin structure.
- γ-CTN (or plakoglobin) is a component of desmosomes and contains armadillo repeats.
- δ-CTN is expressed in the brain and contains 10 armadillo repeats.
- p120 CTN is another member of the CTN family.
3D Structures of Catenin
Updated on 29-November-2015
References
- ↑ Weis WI, Nelson WJ. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem. 2006 Nov 24;281(47):35593-7. Epub 2006 Sep 27. PMID:17005550 doi:http://dx.doi.org/10.1074/jbc.R600027200
