CD47

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<StructureSection load='2jjs' size='450' side='right' scene='53/538855/Cv/1' caption='Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions [[2jjs]]'>
<StructureSection load='2jjs' size='450' side='right' scene='53/538855/Cv/1' caption='Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions [[2jjs]]'>
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</StructureSection>
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__TOC__
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== Function ==
== Function ==
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CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain.
CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain.
*<scene name='53/538855/Cv/2'>CD47 with SIRP α (cyan) and I-ions</scene> ([[2jjs]]).<ref>PMID:18657508</ref>
*<scene name='53/538855/Cv/2'>CD47 with SIRP α (cyan) and I-ions</scene> ([[2jjs]]).<ref>PMID:18657508</ref>
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</StructureSection>
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__TOC__
== 3D Structures of CD47 ==
== 3D Structures of CD47 ==

Revision as of 11:12, 29 November 2015

Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions 2jjs

Drag the structure with the mouse to rotate

Contents

3D Structures of CD47

Updated on 29-November-2015

2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate

References

  1. ↑ Chao MP, Weissman IL, Majeti R. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol. 2012 Apr;24(2):225-32. doi: 10.1016/j.coi.2012.01.010. Epub, 2012 Feb 4. PMID:22310103 doi:http://dx.doi.org/10.1016/j.coi.2012.01.010
  2. ↑ Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508 doi:10.1016/j.molcel.2008.05.026

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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