We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Acid phosphatase
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
'''Acid phosphatase''' (ACP, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H<sub>2</sub>O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.<br /> | '''Acid phosphatase''' (ACP, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H<sub>2</sub>O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.<br /> | ||
| - | '''Prostatic ACP''' (PSAP) is produced by the prostate.<br /> | + | *'''Prostatic ACP''' (PSAP) is produced by the prostate.<br /> |
| - | '''Purple ACP''' (PAP) or '''tartrate-resistant ACP''' contains a dinuclear Fe center and their oxidized form in solution maintains a purple color. <br /> | + | *'''Purple ACP''' (PAP) or '''tartrate-resistant ACP''' contains a dinuclear Fe center and their oxidized form in solution maintains a purple color. <br /> |
| - | '''Histidine ACP''' (HAP) catalyzes the transfer of phosphoryl group using an active-site histidine. | + | *'''Histidine ACP''' (HAP) catalyzes the transfer of phosphoryl group using an active-site histidine. |
== Disease == | == Disease == | ||
Revision as of 11:42, 30 November 2015
Contents |
Function
Acid phosphatase (ACP, EC number 3.1.3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.
- Prostatic ACP (PSAP) is produced by the prostate.
- Purple ACP (PAP) or tartrate-resistant ACP contains a dinuclear Fe center and their oxidized form in solution maintains a purple color.
- Histidine ACP (HAP) catalyzes the transfer of phosphoryl group using an active-site histidine.
Disease
PSAP is found in increased amounts in patients who have prostate cancer.
Relevance
PSAP was used as a prostate cancer marker before the develpement of prostate specific antigen (PSA) as one.
3D Structures of acid phosphatase
Updated on 30-November-2015
