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4ue1

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'''Unreleased structure'''
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==Structure of the stapled peptide YS-01 bound to MDM2==
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<StructureSection load='4ue1' size='340' side='right' caption='[[4ue1]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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The entry 4ue1 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ue1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UE1 FirstGlance]. <br>
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Authors: Tan, Y.S., Reeks, J., Brown, C.J., Jennings, C.E., Eapen, R.S., Tng, Q.S., Thean, D., Ying, Y.T., Gago, F.J.F., Lane, D.P., Noble, M.E.M., Verma, C.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JN:2-METHYL-D-NORLEUCINE'>2JN</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ud7|4ud7]]</td></tr>
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Description: Structure of the stapled peptide YS-01 bound to MDM2
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ue1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ue1 OCA], [http://pdbe.org/4ue1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ue1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ue1 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Brown, C.J]]
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== Disease ==
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[[Category: Eapen, R.S]]
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[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
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[[Category: Lane, D.P]]
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== Function ==
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[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Brown, C J]]
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[[Category: Eapen, R S]]
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[[Category: Gago, F J.F]]
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[[Category: Jennings, C E]]
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[[Category: Lane, D P]]
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[[Category: Noble, M E.M]]
[[Category: Reeks, J]]
[[Category: Reeks, J]]
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[[Category: Noble, M.E.M]]
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[[Category: Tan, Y S]]
[[Category: Thean, D]]
[[Category: Thean, D]]
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[[Category: Jennings, C.E]]
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[[Category: Tng, Q S]]
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[[Category: Tan, Y.S]]
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[[Category: Ying, Y.T]]
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[[Category: Tng, Q.S]]
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[[Category: Gago, F.J.F]]
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[[Category: Verma, C]]
[[Category: Verma, C]]
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[[Category: Ying, Y T]]
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[[Category: Ligase-peptide complex]]

Revision as of 20:20, 13 January 2016

Structure of the stapled peptide YS-01 bound to MDM2

4ue1, resolution 1.45Å

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