4v0s
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative== |
| - | + | <StructureSection load='4v0s' size='340' side='right' caption='[[4v0s]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4v0s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V0S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HN:(1R,2S,4S,5R)-2-(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL-1,4,5-TRIHYDROXY-3-OXOCYCLOHEXANE-1-CARBOXYLIC+ACID'>2HN</scene>, <scene name='pdbligand=7HN:3,4-DIHYDROXY-2-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]BENZOIC+ACID'>7HN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0s OCA], [http://pdbe.org/4v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v0s RCSB], [http://www.ebi.ac.uk/pdbsum/4v0s PDBsum]</span></td></tr> | |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/AROQ_MYCTO AROQ_MYCTO]] Catalyzes a trans-dehydration via an enolate intermediate. |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: 3-dehydroquinate dehydratase]] | ||
[[Category: Gonzalez-Bello, C]] | [[Category: Gonzalez-Bello, C]] | ||
| + | [[Category: Hawkins, A R]] | ||
| + | [[Category: Lamb, H]] | ||
| + | [[Category: Llamas-Saiz, A L]] | ||
[[Category: Maneiro, M]] | [[Category: Maneiro, M]] | ||
| + | [[Category: Otero, J M]] | ||
[[Category: Peon, A]] | [[Category: Peon, A]] | ||
| - | [[Category: | + | [[Category: Raaij, M J.van]] |
| - | + | ||
[[Category: Santiago, C]] | [[Category: Santiago, C]] | ||
| + | [[Category: Binding site]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Lyase]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Shikimis acid pathway]] | ||
| + | [[Category: Substrate specificity]] | ||
| + | [[Category: Type 2 dehydroquinase]] | ||
Revision as of 20:21, 13 January 2016
Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative
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