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4x5h
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==ecDHFR complexed with folate and NADP+ at 500 MPa== |
| - | + | <StructureSection load='4x5h' size='340' side='right' caption='[[4x5h]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4x5h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X5H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x5f|4x5f]], [[4x5g|4x5g]], [[4x5i|4x5i]], [[4x5j|4x5j]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x5h OCA], [http://pdbe.org/4x5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x5h RCSB], [http://www.ebi.ac.uk/pdbsum/4x5h PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dihydrofolate reductase]] | ||
| + | [[Category: Nagae, T]] | ||
[[Category: Watanabe, N]] | [[Category: Watanabe, N]] | ||
[[Category: Yamada, H]] | [[Category: Yamada, H]] | ||
| - | [[Category: | + | [[Category: Oxidoreductase]] |
Revision as of 20:22, 13 January 2016
ecDHFR complexed with folate and NADP+ at 500 MPa
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