4z2d

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'''Unreleased structure'''
 
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The entry 4z2d is ON HOLD until Paper Publication
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==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==
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<StructureSection load='4z2d' size='340' side='right' caption='[[4z2d]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
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Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
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Description: Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr>
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[[Category: Fisher, L.M]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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[[Category: Pan, X.-S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [http://pdbe.org/4z2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [http://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
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[[Category: Sanderson, M.R]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]
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__TOC__
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</StructureSection>
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[[Category: Crevel, I M.T]]
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[[Category: Fisher, L M]]
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[[Category: Laponogov, I]]
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[[Category: Pan, X S]]
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[[Category: Sanderson, M R]]
[[Category: Selvarajah, J]]
[[Category: Selvarajah, J]]
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[[Category: Veselkov, D.A]]
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[[Category: Veselkov, D A]]
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[[Category: Laponogov, I]]
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[[Category: Cleavage complex]]
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[[Category: Crevel, I.M.-T]]
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[[Category: Dna]]
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[[Category: Gyrase]]
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[[Category: Isomerase]]
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[[Category: Quinolone]]

Revision as of 15:25, 14 September 2016

Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae

4z2d, resolution 3.38Å

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